Dramatic advances in the research of male fertility were recently made when scientists developed human sperm from embryonic stem cells. Researchers at the Newcastle University and North East England Stem Cell Institute have developed the method which involves cultivating male stem cells into germ line stem cells which are then prompted to undergo meiosis and form mature sperm, namely, “In Vitro Derived sperm”. The procedure was also attempted with female stem cells however after forming into early stage spermatagonia the process ceased, signifying to researches that the Y chromosome is necessary for meiosis and sperm maturation.
As the topic of stem cell research is still under debate, researchers have stated that the sperm will not be used in fertility treatment as it is prohibited in the UK and also holds no value to their study. Researchers are hoping that by gaining a comprehensive understanding of the formation of sperm they can provide new alternatives for couples suffering infertility problems, including helping them have a child that is genetically their own. It will also allow scientists to study how these cells are affected by toxins, possibly helping young boys who have become infertile due to medications they have had administered. Researchers believe that studying the formation of sperm could also lead to a better understanding of how genetic diseases are passed on. This research could ultimately bring relief to the frustrations of thousands of couples who struggle with infertility.
Newcastle University (2009, July 8). Human Sperm Created From Embryonic Stem Cells. ScienceDaily. Retrieved August 18, 2009, from http://www.sciencedaily.com /releases/2009/07/090708073843.htm
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